Druggability | GasCanBase

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Impact of nsSNPs on Drug Binding

Drug binding analysis was carried out to confirm the structural variation and possible dysfunction of the final product of each 40 GC genes between wild type and mutant model. We have utilized DrugBank to select the drugs against the protein receptor of 40 GC genes. DrugBank suggested that some drugs were available against the corresponding protein of 10 GC genes. Thereafter, we have performed molecular docking analysis between the suggested drugs and protein receptor of 10 GC genes. We have found the result of 8 GC genes which bound the different interacting residues with different binding affinity where the same docking area was used for docking runs. These results confirmed the structural variation and drug could not be effective against mutant model if the individuals with this polymorphism.

To see the impact on drug binding affinity and interactions in wild and mutant structures

To see the results of druggability analysis of gastric cancer genes

To visualize the results graphically, go through the images below.

Fig S6. Drug binding between ABCB1 and A

Drug binding between ABCB1 and Amrinone drug. A. Wild B. Mutant

Fig S7. Drug binding between ABCB1 and D

Drug binding between ABCB1 and Dinoprostone drug. A. Wild B. Mutant

Fig S8. Drug binding between ABCB1 and D

Drug binding between ABCB1 and Dipyridamole drug. A. Wild B. Mutant

Fig S9. Drug binding between ABCB1 and N

Drug binding between ABCB1 and Nelfinavir drug. A. Wild B. Mutant

Fig S10. Drug binding between ABCB1 and

Drug binding between ABCB1 and Rifampicin drug. A. Wild B. Mutant

Fig S11. Drug binding between ABCB1 and

Drug binding between ABCB1 and Sulfinpyrazone drug. A. Wild B. Mutant

Fig S12. Drug binding between ABCB1 and

Drug binding between ABCB1 and Verapamil drug. A. Wild B. Mutant

Fig S13. Drug binding between DCC and Et

Drug binding between DCC and Ethanol drug A. Wild B. Mutant

Fig S14. Drug binding between KIT and Im

Drug binding between KIT and Imatinib drug. A. Wild B. Mutant

Fig S15. Drug binding between MMP2 and c

Drug binding between MMP2 and captopril drug. A. Wild B. Mutant

Fig S16. Drug binding between MTHFR and

Drug binding between MTHFR and Flurouracil drug. A. Wild B. Mutant

Fig S17. Drug binding between MTHFR and

Drug binding between MTHFR and Methorexate Acid drug A. Wild B. Mutant

Fig S18. Drug binding between PTGS2 and

Drug binding between PTGS2 and Lenalidomide drug. A. Wild B. Mutant

Fig S19. Drug binding between PTGS2 and

Drug binding between PTGS2 and Mafenamic Acid drug A. Wild B. Mutant

Fig S20. Drug binding between TNF and Am

Drug binding between TNF and Amrinone Acid drug A. Wild B. Mutant

Fig S21. Drug binding between VEGFA and

Drug binding between VEGFA and Gliclazide drug. A. Wild B. Mutant

Fig S6. Drug binding between ABCB1 and A

Drug binding between ABCB1 and Amrinone drug. A. Wild B. Mutant

Fig S6. Drug binding between ABCB1 and A

Drug binding between ABCB1 and Amrinone drug. A. Wild B. Mutant

Fig S6. Drug binding between ABCB1 and A

Drug binding between ABCB1 and Amrinone drug. A. Wild B. Mutant

Fig S6. Drug binding between ABCB1 and A

Drug binding between ABCB1 and Amrinone drug. A. Wild B. Mutant

Fig S6. Drug binding between ABCB1 and A

Drug binding between ABCB1 and Amrinone drug. A. Wild B. Mutant

Fig S6. Drug binding between ABCB1 and A

Drug binding between ABCB1 and Amrinone drug. A. Wild B. Mutant

Fig S6. Drug binding between ABCB1 and A

Drug binding between ABCB1 and Amrinone drug. A. Wild B. Mutant

Fig S6. Drug binding between ABCB1 and A

Drug binding between ABCB1 and Amrinone drug. A. Wild B. Mutant

Fig S6. Drug binding between ABCB1 and A

Drug binding between ABCB1 and Amrinone drug. A. Wild B. Mutant

Fig S6. Drug binding between ABCB1 and A

Drug binding between ABCB1 and Amrinone drug. A. Wild B. Mutant

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